
Discoloration Defense Serum
R2350.00
The 30ml Discoloration Defense Serum from SkinCeuticals contains 3% tranexamic acid to specifically target persistent dark spots and melasma. This corrective treatment helps even out skin tone for a clearer and more luminous complexion. Apply it twice daily after cleansing to help reduce the appearance of visible pigmentation.
Earn 1175 SK1N Points with this purchase
The 30ml Discoloration Defense Serum from SkinCeuticals contains 3% tranexamic acid to specifically target persistent dark spots and melasma. This corrective treatment helps even out skin tone for a clearer and more luminous complexion. Apply it twice daily after cleansing to help reduce the appearance of visible pigmentation.
Corrects various types of dark spots including melasma and post-inflammatory hyperpigmentation.
- Strength
- Niacinamide Kojic Acid Tranexamic Acid HEPES
- Size
- 30ml
- Application
- Serum
- Concern
- Pigmentation
- Skin Type
- Normal or Combination, Oily, Acne-Prone, Mature, Sun Damaged
- Age
- 20s, 30s, 40s
Apply 3-5 drops of Discoloration Defense twice a day after cleansing in the morning and evening. If using in the morning, apply after your SkinCeuticals antioxidant and follow with a SkinCeuticals broad-spectrum sunscreen. Limit sun exposure while using this product & always use a good quality, high factor, broad spectrum sunscreen every day - compliance is vital when treating pigmentation. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Full Ingredients (INCI)
AQUA / WATER, BUTYLENE GLYCOL, NIACINAMIDE, HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID, GLYCERIN, TRANEXAMIC ACID, PROPYLENE GLYCOL, HYDROXYETHYL UREA, KOJIC ACID, CAPRYLYL GLYCOL, ALLANTOIN, CHLORPHENESIN, XANTHAN GUM, DISODIUM EDTA

Treatment / iS Clinical
Active Peel System
R2254.00
Active Peel System from iS Clinical is a professional-grade, two-step resurfacing treatment across 15 treatment sets. It combines botanical acids, copper tripeptide-1, and vitamin A to improve clarity and reduce signs of pigmentation. This system provides a gentle yet effective exfoliation, leaving your skin feeling hydrated and protected for a more radiant appearance.
Earn 1127 SK1N Points

Cleanser / mesoestetic
Brightening Foam
R1120.00
Brightening Foam by mesoestetic is a creamy facial cleanser that removes impurities while targeting pigmentation. With glycolic acid and lactic acid, it helps dull skin look more radiant and even. Simply massage a small amount onto damp skin to leave your complexion feeling soft and clear.
Earn 560 SK1N Points

Serum / mesoestetic
Melan Tran3x Concentrate
R2862.00
The 30ml bottle of Melan Tran3x Concentrate from mesoestetic is a potent depigmenting serum. Containing tranexamic acid, the Enzymacid complex, and niacinamide, it works to reduce the appearance of persistent dark spots and maintain results after professional treatments. It is lightweight and absorbs quickly, making it easy to incorporate into your morning and evening skincare routine.
Earn 1431 SK1N Points

Serum / mesoestetic
AOX Ferulic
R1880.00
AOX Ferulic by mesoestetic is an advanced antioxidant concentrate that defends against environmental stressors. Featuring L-ascorbic acid, ferulic acid, and the protech-cell complex, it brightens your complexion and provides daily protection. Apply a few drops each morning to keep your skin looking radiant and healthy.
Earn 940 SK1N Points
What is Discoloration Defense Serum used for?
Discoloration Defense Serum is a serum from SkinCeuticals, formulated for pigmentation. Corrects various types of dark spots including melasma and post-inflammatory hyperpigmentation.
How do I use Discoloration Defense Serum?
Apply 3-5 drops of Discoloration Defense twice a day after cleansing in the morning and evening. If using in the morning, apply after your SkinCeuticals antioxidant and follow with a SkinCeuticals broad-spectrum sunscreen. Limit sun exposure while using this product & always use a good quality, high factor, broad spectrum sunscreen every day - compliance is vital when treating pigmentation. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
What are the key ingredients in Discoloration Defense Serum?
Discoloration Defense Serum is built around Niacinamide Kojic Acid Tranexamic Acid HEPES. The full INCI list is published on this page, so you can check every ingredient before you commit.
Which skin types is Discoloration Defense Serum suitable for?
Discoloration Defense Serum is formulated for normal or combination, oily, acne-prone, mature, sun damaged. If your skin is reactive, patch-test on the inner forearm 24 hours before first use and introduce it slowly.
How long does Discoloration Defense Serum take to work?
Brightening is gradual. Expect a visibly more even tone after 8–12 weeks, and keep using daily SPF or the pigment will return. Results depend on consistency, and on daily broad-spectrum SPF, which protects the progress you have made.
Can I use Discoloration Defense Serum with retinol and vitamin C?
Yes, with care. Apply water-based formulas before oil-based ones, and keep strong acids and retinol in separate sessions: vitamin C suits the morning, retinol the evening.
Is Discoloration Defense Serum safe to use during pregnancy or breastfeeding?
Some actives in Discoloration Defense Serum, including retinoids and high-strength acids, are generally avoided during pregnancy and breastfeeding. Please speak to your treating doctor or our skincare advisor before use, and favour gentle, pregnancy-safe alternatives.
How long does one 30ml serum last?
Discoloration Defense Serum is supplied as 30ml. Used at the recommended amount twice daily, most people find a bottle of this size lasts roughly two to three months, though that depends on how far you take it, and whether you cover the neck and décolleté as well as the face.
Is Discoloration Defense Serum genuine, and where can I buy it in South Africa?
Every Discoloration Defense Serum sold on SK1N is sourced through authorised SkinCeuticals distribution and dispatched from South Africa, not grey-market stock. Standard delivery is a flat R150 nationwide, and our consultants can confirm it suits your routine before you buy.
Customer Reviews
This product has not been reviewed yet. Share your experience using the form.
Frequently Bought Together
Complete the routine: products most commonly paired with this one.

Cleanser / mesoestetic
Purifying Mousse
R1230.00
Purifying Mousse by mesoestetic is a foaming cleanser that helps control oil and prevent breakouts. With chlorhexidine, salicylic acid, and lactic acid, it deep cleanses your pores while maintaining a fresh feel. Pump a small amount onto damp skin, massage well, and rinse for a clearer complexion.
Earn 615 SK1N Points

Cream / NeoStrata
Skin Active Rebound Sculpting Cream
R1800.00
NeoStrata Skin Active Rebound Sculpting Cream is designed to address signs of ageing using polyhydroxy acids and maltobionic acid. This gentle cream works to renew the skin surface and improve overall appearance. When massaged into wet skin, it creates a light lather that leaves your complexion feeling revitalized and refreshed after each use.
Earn 900 SK1N Points

SPF / Heliocare
Gelcream Color SPF 50
R600.00
Gelcream Color SPF 50 by Heliocare provides high-level sun protection while evening out your skin tone with a hint of tint. Infused with Fernblock and iron oxides, it guards against damage while offering a natural, healthy glow. The formula blends effortlessly into the face and neck, making it a reliable final step in your daily routine.
Earn 300 SK1N Points







